Hi Latifa,
This is a very generic question.
It is a big subject, but as you can guess, you will have to check the peformance of all the tiers and components indiviually.
As for App ->
Oracle Concurrent Processing Analyzer – Doc ID 1411723.1
Express Diagnosis of Oracle E-Business Suite Release 12 Upgrade Performance Issues Note 1583752.1
Oracle E-Business Suite Recommended Performance Patches Note 244040.1
Oracle Fusion Middleware - Performance and Tuning for Oracle WebLogic Server 11g Release 1 (10.3.6)
12.2 Debgging Managed Server Performance and Stability Note 1908444.1 Internal Only
PRACTICAL ORACLE E-BUSINESS SUITE -> CHAPTER 13 ORACLE E-BUSINESS SUITE 12.2 PERFORMANCE RECOMMENDATIONS
As for DB ->
Troubleshooting Oracle E-Business Performance Problems Using the Database Diagnostics and Tuning Features (Doc ID 1540650.1)
PRACTICAL ORACLE E-BUSINESS SUITE -> CHAPTER 13 ORACLE E-BUSINESS SUITE 12.2 PERFORMANCE RECOMMENDATIONS
You also need to ensure that the best practices are applied.